Clinical Significance of p53 and Ki-67 Expression in Colorectal Cancer
Journal of the Korean Society of Coloproctology
;
: 107-112, 2009.
Article
in Korean
| WPRIM
| ID: wpr-32057
ABSTRACT
PURPOSE:
This study aimed to evaluate the clinical significance of p53 and Ki-67 expressions in patients with colorectal cancer.METHODS:
Immunohistochemical expressions of p53 and Ki-67 in 205 patients with colorectal cancer were examined. Results were correlated with clinical and pathological parameters.RESULTS:
Overexpression of p53 was significantly associated with a proximal location of the tumor (P=0.031) and with lymph node involvement (P=0.030); however, Ki-67 expression was not correlated with any of the clinicopathological variables. Positive p53 staining was significantly associated with a higher level of Ki-67 (P=0.009).CONCLUSIONS:
Overexpression of p53 was strongly correlated with lymph node metastasis in colorectal cancer; thus, p53 may be used as a possible prognostic marker in patients with colorectal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Colorectal Neoplasms
/
Lymph Nodes
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Coloproctology
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS