Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance / 癌症
Chinese Journal of Cancer
;
(12): 365-370, 2013.
Article
in English
| WPRIM
| ID: wpr-320580
ABSTRACT
The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling cascade. In addition, FOXM1 and FOXO3a also antagonize each other's activity by competitively binding to the same target genes, which are involved in chemotherapeutic drug sensitivity and resistance. Understanding the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients, and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Signal Transduction
/
Drug Resistance, Neoplasm
/
Phosphatidylinositol 3-Kinases
/
Therapeutic Uses
/
Drug Therapy
/
Proto-Oncogene Proteins c-akt
/
Forkhead Transcription Factors
/
Carcinogenesis
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2013
Type:
Article
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