Therapeutic effect of early administration of oral ibuprofen in very low birth weight infants with patent ductus arteriosus / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 502-505, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-320609
ABSTRACT
<p><b>OBJECTIVE</b>To study therapeutic effect and safety of early administration of oral ibuprofen in very low birth weight infants (VLBWIs) with patent ductus arteriosus (PDA).</p><p><b>METHODS</b>A total of 64 symptomatic VLBWIs (within 24 hours after birth) with PDA confirmed by bedside Color Doppler ultrasound were randomly divided into two groups treatment and control (n=32 each). The treatment group was orally administered ibuprofen within 24 hours after birth at 10 mg/kg, followed 24 hours later by a second dose of 5 mg/kg and 48 hours later by a third dose of 5 mg/kg. The control group was treated with placebo (normal saline) at 1 mL/kg, followed 24 hours later by a second dose of 0.5 mL/kg and 48 hours later by a third dose of 0.5 mL/kg. The therapeutic efficacies and adverse effects in both groups were observed.</p><p><b>RESULTS</b>The treatment group showed a significantly higher closure rate of ductus arterious than the control group after one course of treatment (84% vs 41%; P<0.01). The incidence rates of periventricular leukomalacia and bronchopulmonary dysplasia were significantly lower in the treatment group than in the control group (P<0.05). The duration of mechanical ventilation and mean hospitalization time were significantly shorter in the treatment group than in the control group (P<0.05). There were no significant differences in the incidence rates of intraventricular hemorrhage, early pulmonary hemorrhage and necrotizing enterocolitis between the two groups (P>0.05). No obvious adverse effects were observed in both groups.</p><p><b>CONCLUSIONS</b>Early administration of oral ibuprofen for treatment of PDA in VLBWIs can decrease the incidence rates of some early complications and shorten hospitalization time, but causes no significant adverse effects.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anti-Inflammatory Agents, Non-Steroidal
/
Ibuprofen
/
Administration, Oral
/
Infant, Very Low Birth Weight
/
Drug Therapy
/
Ductus Arteriosus, Patent
/
Length of Stay
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2012
Type:
Article
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