Spectrum of gene deletion in 471 children with α-thalassemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 264-266, 2012.
Article
in Zh
| WPRIM
| ID: wpr-320669
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the distribution of common α-thalassemia gene deletion in children.</p><p><b>METHODS</b>Blood cell analysis was performed on children who visited the clinic of the Foshan Women and Children's Hospital. Blood samples (2 mL, EDTA anticoagulant) was collected from children with MCV<82 fl for analysis of α-thalassemia gene using the GAP-PCR method.</p><p><b>RESULTS</b>MCV<82 fl was found in 1341 children. Of the 1341 children, 471 (35.1%) were diagnosed with α-thalassemia. The prevalence of α-thalassemia increased with increasing age. --SEA was a major type of α-thalassemia gene deletion (75.3%), followed by -a3.7 (17.0%) and -a4.2 (7.7%) in the 471 patients. The top three genotypes were --SEA/aa (73.2%), aa/-a3.7 (12.5%) and --SEA/-a3.7 (5.5%).</p><p><b>CONCLUSIONS</b>Genetic testing is necessary for the diagnosis of α-thalassemia in children with MCV<82 fl. --SEA is a common type of α-thalassemia gene deletion, and -SEA/aa is a common gene type of α-thalassemia in the subjects of this study.</p>
Full text:
1
Index:
WPRIM
Main subject:
Blood
/
Gene Deletion
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Alpha-Thalassemia
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Erythrocyte Indices
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Gene Frequency
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Genetics
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2012
Type:
Article