Comparisons of efficacy of different pulmonary surfactants for the treatment of neonatal respiratory distress syndrome / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 253-255, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-320672
ABSTRACT
<p><b>OBJECTIVE</b>To compare the clinical efficacy of imported pulmonary surfactant (PS) pig lung phospholipids injection (pig PS) and domestic cattle lung surface-active agent (cattle PS) for the treatment of neonatal respiratory distress syndrome (NRDS).</p><p><b>METHODS</b>A total of 180 cases of grade IV NRDS receiving pig PS (n=90) or cattle PS treatment (n=90) were enrolled. The blood gas analysis and chest X-ray results and the incidence of complications after treatment, and hospitalization time and cost were compared between the two treatment groups.</p><p><b>RESULTS</b>The efficiency rate in the pig PS group (97%) was higher than in the catle PS group (83%) (P<0.01). The cure rate in the pig PS group was also higher than in the cattle PS group (84% vs 66%; P<0.01). The incidence of pneumothorax in the pig PS group was lower than in the cattle PS group (3% vs 7%; P<0.05). The hospitalization time in the pig PS group was shorter than in the cattle PS group (21 ± 4 days vs 23 ± 4 days; P<0.05). There were no significant differences in the total hospitalization cost between the two groups.</p><p><b>CONCLUSIONS</b>Pig PS seems to be superior to cattle PS in the treatment of grade IV NRDS.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory Distress Syndrome, Newborn
/
Swine
/
Blood Gas Analysis
/
Pulmonary Surfactants
/
Therapeutic Uses
/
Drug Therapy
/
Economics
/
Hospitalization
/
Length of Stay
Type of study:
Health economic evaluation
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2012
Type:
Article
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