Phylogenetic analysis of sporadic hepatitis E virus in Eastern China / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 1269-1272, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-321072
ABSTRACT
<p><b>OBJECTIVE</b>To understand phylogenetic characteristics of sporadic hepatitis E virus (HEV) in eastern China.</p><p><b>METHODS</b>Four hundred and thirteen sera were collected from sporadic hepatitis E cases in 14 second- or first-class hospitals in Eastern China from 2005 to 2008 and detected with a nested RT-PCR assay. Partial nucleotide sequences of the HEV isolates were determined for phylogenetic analysis with prototype sequences in the GenBank.</p><p><b>RESULTS</b>The male-to-female sex ratio of the patients was 1.751 with 61.5% of them aged 40 - 69 years old. HEV RNA was detected in 140 out of 413(34%)serum samples. Phylogenetic analysis revealed that all the 140 HEV isolates belonged to genotype IV, sharing 77.9% - 88.3%, 80.8% - 90.6%, 73.4% - 85.2% and 91.0% - 95.4% nucleotide sequence identities with prototype I, II, III and IV HEV isolates respectively.</p><p><b>CONCLUSION</b>It was evident that genotype IV HEV served as the main causative agent of sporadic HEV infection in Eastern China. However the viral origin and evolution needs further clarification.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Virology
/
RNA, Viral
/
Molecular Sequence Data
/
Base Sequence
/
China
/
Epidemiology
/
Classification
/
Hepatitis E virus
/
Hepatitis E
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2009
Type:
Article
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