Angiotensin converting enzyme gene and exercise-induced silent myocardial ischemia in type 2 diabetes mellitus / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 206-208, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-321124
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between angiotensin converting enzyme (ACE) gene and exercise-induced silent myocardial ischemia (SI) in patients with type 2 diabetes mellitus.</p><p><b>METHODS</b>One hundred and eight patients suffering from type 2 diabetes mellitus with normal rest electrocardiograph and 50 healthy individuals were selected randomly. SI was diagnosed with treadmill exercise test and ACE genotypes were detected with PCR.</p><p><b>RESULTS</b>(1) The control group and type 2 diabetes mellitus group had similar distribution of ACE genotypes and alleles (P>0.05). Compared with the non-SI group, the SI group had significantly higher ACE D allele prevalence (Chi-square=4.501, P<0.05); however, the two groups had similar prevalence of ACE genotypes (P>0.05). (2) There were no significant differences in clinical characteristics and serum lipoproteins among the three ACE genotypes (II, DD,ID) of type 2 diabetes mellitus (P>0.05). (3) The prevalence of SI in DD group was found to be 68.2%, which was significantly higher than that in II genotype group (39.5%, Chi-square=4.593, P<0.05).</p><p><b>CONCLUSION</b>ACE D allele increases the risk of SI in type 2 diabetes mellitus.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Blood
/
Exercise
/
Polymerase Chain Reaction
/
Myocardial Ischemia
/
Peptidyl-Dipeptidase A
/
Genetic Predisposition to Disease
/
Diabetes Mellitus, Type 2
/
Diagnosis
/
Gene Frequency
Type of study:
Diagnostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2005
Type:
Article
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