Association of schizophrenia with a promoter polymorphism in the dopamine D2 receptor gene / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 94-95, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-321148
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of -141C insert/delete polymorphism with schizophrenia in Wuhan of Hubei province.</p><p><b>METHODS</b>A case-control study was conducted to analyze the polymorphism in the D(2) receptor gene promoter region with schizophrenia. A total of 120 cases of schizophrenia diagnosed according to CCMD-II R criteria and 100 normal controls were recruited in the study.</p><p><b>RESULTS</b>In this sample, the allele and genotype showed statistically significant differences between patients and normal controls (P<0.05).Especially, the frequency of -141C del was 11% in patients and 18% in control(OR 0.55, 95% CI 0.30-0.96; P<0.05). This allele was less common in schizophrenia than in normal controls (P<0.05).</p><p><b>CONCLUSION</b>The -141C del polymorphism is associated with schizophrenia.The polymorphism may modify the association with other factors. Possibly -141C del in the DRD(2) promoter region is a strong candidate for a protective factor for this trait.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Schizophrenia
/
Polymerase Chain Reaction
/
Promoter Regions, Genetic
/
Receptors, Dopamine D2
/
Diagnosis
/
Alleles
/
Gene Frequency
/
Genetics
/
Genotype
Type of study:
Diagnostic study
/
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2005
Type:
Article
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