Surfactant protein A gene polymorphisms in chronic obstructive pulmonary disease / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate whether polymorphism in gene for surfactant protein A(SPA) has any bearing on individual susceptibility to the development of chronic obstructive pulmonary disease(COPD).</p><p><b>METHODS</b>The genotypes of 88 patients with COPD and 87 healthy smoking subjects as controls were tested with polymerase chain reaction followed by restriction fragment length polymorphism analysis for SPA gene.</p><p><b>RESULTS</b>In COPD group, the frequencies of +186 locus genotypes AA, AG and GG were 86.4%, 12.5% and 1.1%i respectively and in the control group, these were 66.7%, 27.6% and 5.7%; the frequencies of polymorphic genotypes or alleles showed statistically significant difference between the COPD group and the control group(P<0.05). The frequencies of polymorphic genotypes at +655 locus and +667 loci showed no significant difference between the COPD group and the control group in(P>0.05).</p><p><b>CONCLUSION</b>Genetic polymorphism in SPA is associated with the development of COPD in the Chinese Hans.</p>