Influential factors on congenital gastrointestinal malformation: a hospital-based case-control study / 中华流行病学杂志

ABSTRACT

Objective To investigate the influential factors on congenital gastrointestinal malformation and to provide evidences for prevention.Methods A hospital-based case-control study was conducted among infants with or without congenital gastrointestinal malformation at Children's hospital of Hunan province,from April 2011 to August 2012.Parents of 120 cases with congenital gastrointestinal malformation and another 170 controls were asked to fill in a questionnaire.Data was analyzed using SPSS 18.0 software.Results Congenital gastrointestinal malformation was associated with intakes of maternal medication (OR=3.35,95％CI1.51-7.41) and folic acid (OR=0.28,95％CI0.15-0.52),exposure to paints (OR=5.05,95％CI1.32-19.29) and pesticides (OR=15.20,95％CI1.55-148.99) prior to or during pregnancy,and also associated with medication intake of the father (OR=3.70,95％CI1.13-12.10),smoking (OR=2.39,95％CI1.24-4.62),drinking alcohol (OR=2.47,95％CI1.20-5.07),exposure to the agents for indoor cleaning (OR=16.42,95％ CI1.71-157.92) and exposure to paints (OR=9.92,95％ CI2.66-36.98) before conception.Conclusion Congenital gastrointestinal malformation was affected by multiple factors.Potential risk factors for congenital gastrointestinal malformation would include intakes of medication by the pregnant mother,exposure to paints exposure and pesticide exposure before or during pregnancy,and medication intake by the father,smoking,drinking alcohol,exposure to indoor cleaning agents/paint before conception.The amount of folic acid intake by mother before or during pregnancy was likely to reduce the risk for congenital gastrointestinal malformation.