Feasibility of multi models targeting home pain alleviation service used on 220 cases with advanced cancer / 中华流行病学杂志

ABSTRACT

Objective To investigate the feasibility and effectiveness of multiple modes on home pain alleviation service used for advanced cancer patients to in prove clinical therapy services.Methods The study was involved with 220 patients with advanced cancers to provide them with multimodal analgesia services at home,from February 2010 to February 2013.Patients in this study had been taking both opioid treatments.They were randomly devided into two groups with the number as 112 and 10g and were given different doses of morphine or other drugs.During the period of observation,data was collected under the M.D.Anderson symptom Inventory (MDASI) score and classification of score on pain.Results Differences of pain scores in the two groups and the MDASI score were significant and presented as skewed distribution.Scores on pain score were between groups were significantly different (Z=-9.735,P＜0.001).The average rankings of A group and B group were 76.68 and 162.79 respectively.Under the application of 0.4 mg alprazolam,the degree of pain alleviation seemed to be better.The differences on comprehensive scores between different drug groups were statistically significant(Z=-13.334,P＜0.001).The average rankings of groups A and B were respectively 59.87 and 179.08.Under the use of 0.4 mg of alprazolam,the results could be considered to show better improvements in symptomatic patients.Application of 0.4 mg alprazolam on patients with advanced-cancer-induced-pain showed a better symptomatic improvement than using morphine.Conclusion Patients with advanced cancers receiving multimodal analgesia short-term sedation therapies at home,showed both ideal feasibility and good effectiveness.When morphine was combined used with midazolam at home,a better outcome could be seen in pain-releasing on patients with cancer,than single morphine analgesia was used.