Effects of neuraxial block and general anesthesia on tumor metastasis in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2218-2220, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-321724
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of different anesthesia methods on immune surveillance and tumor metastasis in tumor-bearing rats.</p><p><b>METHODS</b>Seventy-two Fischer 344 rats were randomly assigned into 3 equal groups and anesthetized for 1 h with ketamine (group K), propofol (group P), or neuraxial block (group B). All the rats were subjected to laparotomy followed by intravenous injection of MADB106 tumor cells, and 24 h after the injection, the number and activity of circulating CD3(+), CD4(+), CD8(+), and D4(+)/CD8(+) lymphocyte subsets and NK cellèCD161a(+)éwere assessed. Three weeks later, the lung metastases were counted.</p><p><b>RESULTS</b>Compared with those in group B, the numbers of CD3(+), CD4(+), CD8(+), and CD161a(+) lymphocytes and the activity of circulating NK cells were significantly reduced, and the lung metastases of MADB106 increased significantly in groups K and P (P<0.05 or 0.01 ). The activity of immune surveillance in group K was significantly lower than that in group P except for CD8(+) cells, and the tumor metastases in group K increased significantly in comparison with those in group P (P<0.05 or 0.01).</p><p><b>CONCLUSION</b>Neuraxial block provides protection of the activity of immune surveillance and reduces tumor metastases in tumor-bearing rats compared with general anesthesia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Rats, Inbred F344
/
General Surgery
/
Breast Neoplasms
/
Random Allocation
/
Propofol
/
Allergy and Immunology
/
Immunologic Surveillance
/
Anesthesia, Epidural
/
Anesthesia, General
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article
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