Clinical analysis of patients with systemic lupus erythematosus and concomitant pulmonary hypertension / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1860-1863, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-321800
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical manifestations, diagnosis and interventions of pulmonary hypertension (PAH) in patients with systemic lupus erythematosus (SLE).</p><p><b>METHODS</b>From January 2001 to December 2007, 798 SLE patients without prior diagnosis were admitted in our hospital, among whom 39 were identified to have concomitant PAH defined by echocardiography. The clinical data of the 39 cases were analyzed retrospectively.</p><p><b>RESULTS</b>The incidence of PAH was 4.9% in these cohort of SLE patients. The 39 SLE patients with concomitant PAH included 5 men and 34 women with a mean age of 34-/+12 years. Positive correlations were found between the occurrence of PAH and the Raynaud phenomenon, fingertip vasculitis, anti-u1RNP antibody positivity, antiphospholipid antibody positivity, pericardial effusion, and interstitial pneumonia (P < 0.05). Patients with higher scores for SLE Disease Activity Index were liable to PAH. The presence of Raynaud phenomenon, fingertip vasculitis, anti-u1RNP antibody positivity, antiphospholipid antibody positivity, pericardial effusion, and interstitial pneumonia is correlated to greater severity PAH with poor prognosis.</p><p><b>CONCLUSION</b>PAH is not a rare concomitant disease in SLE patients. The presence of Raynaud phenomenon, fingertip vasculitis, anti-u1RNP antibody positivity, antiphospholipid antibody positivity, pericardial effusion, and interstitial pneumonia all suggest the likeliness of PAH in SLE patients, and echocardiographic examination may help derive an early diagnosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Raynaud Disease
/
Echocardiography
/
China
/
Epidemiology
/
Retrospective Studies
/
Early Diagnosis
/
Diagnosis
/
Hypertension, Pulmonary
/
Lupus Erythematosus, Systemic
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Screening study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article
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