ROS kinase fusions are not common in Chinese patients with cholangiocarcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 474-478, 2013.
Article
in English
| WPRIM
| ID: wpr-322019
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of different forms of ROS fusions in Chinese patients with cholangiocarcinoma (CCA).</p><p><b>METHODS</b>RT-PCR was employed to examine formalin-fixed and paraffin-embedded CCA samples from stage I-IV patients for detection of ROS fusions involving Fused in Glioblastoma (FIG), solute carrier protein (SLC34A2) and major histocompatibility complex class II invariant chain (CD74). Serpin peptidase inhibitor clade A member 1 (SERPINA1) was detected as the reference gene.</p><p><b>RESULTS</b>In all the 56 CCA samples, 80.4% (45/56) were positive for SERPINA1 expression as evaluable samples. Of these evaluable samples, none expressed the ROS fusions.</p><p><b>CONCLUSION</b>ROS fusions are not common in Chinese CCA patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Bile Duct Neoplasms
/
Protein-Tyrosine Kinases
/
Carrier Proteins
/
Antigens, Differentiation, B-Lymphocyte
/
Histocompatibility Antigens Class II
/
Gene Expression
/
Oncogene Proteins, Fusion
/
Proto-Oncogene Proteins
/
Paraffin Embedding
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Southern Medical University
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS