Effect of topical application of a recombinant adenovirus carrying promyelocytic leukemia gene in a psoriasis-like mouse model / 南方医科大学学报
Journal of Southern Medical University
;
(12): 432-435, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-322030
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of topical treatment with adenovirus-mediated promyelocytic leukemia gene (PML) gene in a psoriasis-like mouse model.</p><p><b>METHODS</b>The effect of adenovirus-mediated PML gene on the granular layer of mouse tail scale epidermis and epithelial mitosis were observed on longitudinal histological sections prepared from the tail skin and vaginal epithelium of the mice.</p><p><b>RESULTS</b>Adenovirus-mediated PML gene significantly inhibited mitosis of mouse vaginal epithelial cells and promoted the formation of granular layer in mouse tail scale epidermis.</p><p><b>CONCLUSION</b>The therapeutic effect of PML gene in the psoriasis-like mouse model may be associated with increased granular cells and suppressed epidemic cell proliferation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psoriasis
/
Skin
/
Therapeutics
/
Transcription Factors
/
Vagina
/
Nuclear Proteins
/
Adenoviridae
/
Administration, Topical
/
Cell Biology
/
Tumor Suppressor Proteins
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2013
Type:
Article
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