Human µ-opioid receptor A118G polymorphism affects epidural patient-controlled analgesia with fentanyl / 南方医科大学学报
Journal of Southern Medical University
;
(12): 309-311, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-322057
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether A118G single nucleotide polymorphisms of the µ-opioid receptor (OPRM1) affects epidural patient-controlled analgesia with fentanyl after caesarean section.</p><p><b>METHODS</b>A total of 100 pregnant women (ASA class I or II) scheduled for elective caesarean section were enrolled in this study. All the patients received spinal-epidural anesthesia and were screened for blood A118G polymorphism. Epidural patient-controlled analgesia with fentanyl was provided postoperatively. The pain scores, incidence of nausea and vomiting, and total self-administered epidural fentanyl dose within 48 h postoperatively were recorded.</p><p><b>RESULTS</b>Ninety-six patients were finally included in this study. The percentages of the genotypes AA, AG, and GG were 36.5% (35 cases), 46.9% (45 cases), and 16.7% (16 cases), respectively. At 12 and 24 h postoperatively, the pain scores and the total fentanyl dose administered were significantly higher in group GG than in groups AA and AG.</p><p><b>CONCLUSION</b>A118G single nucleotide polymorphism affects pain relief and total fentanyl dose administered in epidural patient-controlled analgesia after caesarean section. G118 homozygotes have a poorer response to fentanyl than A118 homozygotes or heterozygotes.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain, Postoperative
/
Pain Measurement
/
Analgesia, Epidural
/
Cesarean Section
/
Fentanyl
/
Receptors, Opioid, mu
/
Polymorphism, Single Nucleotide
/
Genetics
/
Genotype
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2013
Type:
Article
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