High K-induced Epileptiform Activity under GABA Antagonist and Carbamazepine in the Rat Visual Cortex / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 16-23, 2006.
Article
in Korean
| WPRIM
| ID: wpr-32212
ABSTRACT
PURPOSE:
The goal of this study was to investigate the effect of increase of K on the excitability of the visual cortex under GABA antagonist, carbamazepine(CBZP), 6-cyano-7-nitroquinoxaline-dione disodium(CNQX) and D-(-)-2-amino-5-phosphonopentanoic acid(D-AP5) on the increase of K-induced epileptiform activity.METHODS:
The visual cortex slices were obtained from Sprague-Dawley rats. Extracellular recordings were performed to observe the induction of epileptiform discharges perfused by artificial CSF(ACSF) with an increase of K and the effect of 0.5 and 1 mM CBZP, 10 micrometer CNQX and 50 micrometer D-AP5 on the increase of K-induced epileptiform activity.RESULTS:
Spontaneous epileptiform activities were increased by ACSF with 10 mM K under bicuculline compared to 4 mM K. CBZP blocked and 10 micrometer CNQX and 50 micrometer D-AP5 decreased the 10 mM K-induced spontaneous epileptiform activity.CONCLUSION:
An increase of K augmented spontaneous epileptiform activity. This experimental model increased the excitability of the brain, which may be influenced by GABA. CBZP blocked the increase of K-induced epileptiform activity, which showed the increase of excitability. An increase of K-induced epileptiform activity was decreased by CNQX and D-AP5, which may show the attenuation of voltage-dependent low magnesium effect and decrease the excitability in terms of synapse induction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Synapses
/
Visual Cortex
/
Bicuculline
/
Brain
/
Carbamazepine
/
Rats, Sprague-Dawley
/
6-Cyano-7-nitroquinoxaline-2,3-dione
/
GABA Antagonists
/
Gamma-Aminobutyric Acid
/
Magnesium
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Child Neurology Society
Year:
2006
Type:
Article
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