Effect of c-Met inhibitor SU11274 on human colon cancer cell growth / 中华医学杂志(英文版)

ABSTRACT

<p><b>BACKGROUND</b>Colon cancer is one of the major malignancies worldwide and it still remains resistant to much of the currently available chemotherapy. Downregulation of HGF/c-Met signaling pathway is an emerging therapy for cancer treatment.</p><p><b>METHODS</b>In this study, the inhibitory effects of c-Met phosphorylation were observed with SU11274 on different colon cancer cell lines in vitro.</p><p><b>RESULTS</b>The results revealed the significant inhibitory effects of SU11274 on cell proliferation and cell survival, in a time and dose-dependent manner. Furthermore, the inhibitory effects of SU11274 on different subgroups of colon cancer cells via the HGF/c-Met signaling pathway were implicated in this study.</p><p><b>CONCLUSION</b>The results suggested the possible selective therapeutic effects of c-Met inhibitor on colon cancer.</p>