Your browser doesn't support javascript.
loading
Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2489-2494, 2013.
Article in English | WPRIM | ID: wpr-322173
ABSTRACT
<p><b>BACKGROUND</b>The occurrence of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare but severe. We examine the role of pre-HSCT chemotherapeutic exposure, pre-HSCT comorbidities, and transplant-related complications in the development of BOS after allo-HSCT.</p><p><b>METHODS</b>A nested case-control study was designed. Cases with BOS and controls matched for the year of allo-HSCT and length of the follow-up were identified from a cohort of 1646 patients who underwent allo-HSCT for treatment of hematologic malignancies between 2006 and 2011. Antithymocyte globulin was used in the partial matched related and unrelated matched donor HSCT, or patients with severe aplastic anemia.</p><p><b>RESULTS</b>Thirty-six patients suffered from BOS; the mean age at the time of presentation was (32.7 ± 12.4) years, and the mean time to presentation was (474 ± 350) days post-HSCT. A pre-HSCT cyclophosphamide dose of ≥ 3.2 g/m(2)(OR = 8.74, P = 0.025), chronic graft-versus-host disease (moderate to severe) (OR = 12.02, P = 0.000), and conditioning regimens without antithymocyte globulin (OR = 2.79, P = 0.031) were independently associated with BOS.</p><p><b>CONCLUSIONS</b>We found that higher pre-HSCT cyclophosphamide exposure, a conditioning regimen without antithymocyte globulin, and moderate to severe chronic graft-versus-host disease are significantly and independently associated with BOS. Based on these results, we can identify patients who are at a higher risk of developing BOS after allo-HSCT, select a more appropriate therapeutic strategy, and improve the outcome of HSCT recipients.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Transplantation, Homologous / Bronchiolitis Obliterans / Case-Control Studies / Risk Factors / Follow-Up Studies / Hematopoietic Stem Cell Transplantation / Transplantation Conditioning / Graft vs Host Disease Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2013 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Transplantation, Homologous / Bronchiolitis Obliterans / Case-Control Studies / Risk Factors / Follow-Up Studies / Hematopoietic Stem Cell Transplantation / Transplantation Conditioning / Graft vs Host Disease Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2013 Type: Article