Surveillance of Mycoplasma pneumoniae infection among children in Beijing from 2007 to 2012 / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1244-1248, 2014.
Article
in English
| WPRIM
| ID: wpr-322294
ABSTRACT
<p><b>BACKGROUND</b>Mycoplasma pneumonia (M. pneumoniae) is one of the key pathogens of community-acquired pneumonia. A global pandemic of M. pneumoniae has occurred since 2010. The aim of this study was to survey the prevalence of M. pneumoniae in children in Beijing from 2007-2012.</p><p><b>METHODS</b>A total of 3 073 clinical specimens were obtained from pediatric patients with respiratory tract infections from January 2007 to December 2012, and examined by nested polymerase chain reaction. PCR products were visualized by 2% agarose gel electrophoresis, positive products sequenced, and compared with reference sequences in GenBank. Macrolide resistance-associated mutations were also detected for some positive samples.</p><p><b>RESULTS</b>Of the 3 073 specimens, 588 (19.13%) were positive for M. pneumoniae, 12.4% of which were accompanied by viral infections. Positive rates for M. pneumoniae were highest in 2007 and 2012, showing a significant difference when compared with other years. Infections tended to occur in autumn and winter and positive rates were significantly higher for children aged 3-16. The rate of macrolide resistance-associated mutations was 90.7%, and the predominant mutation was an A→G transition (89.92%) at position 2063 in domain V of the 23S rRNA gene.</p><p><b>CONCLUSIONS</b>M. pneumoniae outbreaks occurred in 2007 and 2012 in pediatric patients in Beijing, which is consistent with the global prevalence of M. pneumoniae. M. pneumoniae can cause multi-system infections in children, and may be accompanied with viral infections. We determined that school-age children are more susceptible to this disease, particularly in autumn and winter. Gene mutations associated with macrolide resistance were very common in M. pneumoniae-positive specimens during this period in Beijing.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia, Mycoplasma
/
Virulence
/
Epidemiology
/
Prevalence
/
Macrolides
/
Drug Resistance, Bacterial
/
Therapeutic Uses
/
Drug Therapy
/
Anti-Bacterial Agents
/
Mycoplasma pneumoniae
Type of study:
Prevalence study
/
Screening study
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS