Study of the correlation of papillary thyroid carcinoma's invasion with Ezrin, Moesin and E-Cadherin / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
;
(12): 761-763, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-322476
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Ezrin, Moesin and E-Cadherin on the invasion and metastasis of papillary thyroid carcinoma(PTC).</p><p><b>METHODS</b>The 81 paraffin-embedded specimen of PTC treated in The Second Clinical College of Harbin Medical University from 2005 to 2008 were examined immunohistochemically for Ezrin, Moesin, and E-Cadherin. Normal thyroid tissues adjacent to cancer were control. The correlation of Ezrin, Moesin, and E-Cadherin expressions and clinical features of PTC, including gender, age, tumor size, invasion, lymph node metastasis, and TNM stage, was analyzed.</p><p><b>RESULTS</b>Positive staining rates of Ezrin and Moesin in PTC were significantly higher than those in control (χ(2) were 61.691 and 57.949, P < 0.01, respectively). Positive staining rate of E-Cadherin in PTC was significantly lower than that in control (χ(2) = 64.241, P < 0.01). The positive expression rates of Ezrin and Moesin in PTC increased in the subgroups with age ≥ 45 years, local invasion, lymph node metastasis and stage III-IV, with significant difference respectively (P < 0.01), while the positive expression rate of E-Cadherin in PTC significantly decreased (P < 0.01).</p><p><b>CONCLUSIONS</b>The up-regulation expressions of Ezrin and Moesin and the down-regulation expression of E-Cadherin were associated with the invasion and metastasis of PTC. Combined detection of Ezrin, Moesin and E-Cadherin in PTC might served as an important predictor for the invasion, metastasis and prognosis of PTC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Thyroid Neoplasms
/
Carcinoma
/
Carcinoma, Papillary
/
Cadherins
/
Gene Expression Regulation, Neoplastic
/
Cytoskeletal Proteins
/
Metabolism
/
Microfilament Proteins
/
Neoplasm Invasiveness
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Year:
2011
Type:
Article
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