Measurement of the reactive oxygen species and cytokines in the seminal plasma of leukocytospermic patients / 中华男科学杂志
National Journal of Andrology
;
(12): 103-105, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-322538
ABSTRACT
<p><b>OBJECTIVES</b>To detect the levels of reactive oxygen species (ROS), superoxide dismutase(SOD) and interleukin 8(IL-8) in seminal plasma of infertile patients, and evaluate the possible relationship between those levels.</p><p><b>METHODS</b>Semen was collected from normal donors (15 cases), infertile men without infection (16 cases), and infertile men with infection (leukocytospermia, 11 cases). The routine analysis of semen was accomplished, and then the levels of IL-8, malondialdehyde (MDA), SOD, and white blood cell (WBC) were examined. The correlative analysis between the level of ROS and other parameters in these populations was made.</p><p><b>RESULTS</b>In leukocytospermic group, the levels of MDA, WBC, and IL-8 were higher than those in the other two groups (P < 0.001). Significantly positive correlation was observed between IL-8 and MDA (r = 0.852, P < 0.001) and between the levels of IL-8 and WBC.</p><p><b>CONCLUSIONS</b>These findings suggest that increased oxidative stress in patients with leukocytospermia may cause the increase of IL-8(r = 0.818, P < 0.01). The increased oxidative stress may be due to defect in ROS scavenging system.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Semen
/
Blood
/
Cytokines
/
Reactive Oxygen Species
/
Male Urogenital Diseases
/
Infertility, Male
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2003
Type:
Article
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