The role of transforming growth factor beta superfamily in male germ cell development / 中华男科学杂志
National Journal of Andrology
;
(12): 435-437, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-322569
ABSTRACT
Transforming growth factor beta (TGF beta) superfamily can regulate the development of primordial germ cell (PGC) and gonocyte. TGF beta, bone morphogenetic protein (BMP), activin, inhibin, and anti-Müllerian hormone (AMH), all of which belong to the TGF beta superfamily, can play important roles in male germ cell development. Their downstream signaling molecules, Smads proteins are involved in the signal transduction pathway. In addition, TGF beta and AMH contribute to the apoptosis during development. Understanding this effect will help to elucidate the molecular mechanism of the early development of male reproductive system and the pathogenesis of testicular cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Spermatogenesis
/
Spermatozoa
/
Testicular Hormones
/
Glycoproteins
/
Transforming Growth Factor beta
/
Bone Morphogenetic Proteins
/
Activins
/
Anti-Mullerian Hormone
/
Growth Inhibitors
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2002
Type:
Article
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