Ultrastructural observation of detrusor in BPH patients / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVES</b>To observe the detrusor ultrastructure in BPH patients and to investigate the relationship between detrusor instability and ultrastructure.</p><p><b>METHODS</b>The patients were divided into groups of detrusor instability(DI) and detrusor stability(DS) according to urodynamics examination. The structure of the detrusor were observed by light microscopy and transmission electron microscopy(TEM).</p><p><b>RESULTS</b>The intercellular intermediate junctions and cytoplasmic process junctions in DS were 11.34 +/- 3.23 and 4.26 +/- 1.78 respectively. The intercellular intermediate junctions decreased obviously (3.12 +/- 1.47, P < 0.01) instead of a large amount of cytoplasmic process junctions (26.37 +/- 7.14, P < 0.01) in DI.</p><p><b>CONCLUSIONS</b>There is a close relevance between intercellular junctions and DI. The observation of the ultrastructure of the detrusor is helpful for the diagnosis of BPH with DI and for the clinical treatment.</p>