Study on the relationship of balanced translocation t(1;12) with spermatogenesis / 中华男科学杂志
National Journal of Andrology
;
(12): 247-249, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-322603
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the relationship between chromosome balanced translocation t(1;12) (q24;q24) and spermatogenesis in infertile twin brothers.</p><p><b>METHODS</b>For twin brothers, karotype were determined. The levels of testosterone, FSH and LH were detected. YRRM1, DAZ and DYS240 were analyzed. In younger brother a biopsy was taken from testis.</p><p><b>RESULTS</b>Chromosome analysis for both twin brothers revealed a karotype of 46, XY, t(1;12) (q24;q24). Sperm count was less than 1.0 x 10(6)/ml. There was no deletion for YRRM1, DAZ and DYS240 gene on Y chromosome. Photomicrograph of seminiferous tubules showed the arrest of spermatogenesis.</p><p><b>CONCLUSIONS</b>Chromosome balanced translocation t(1;12) (q24;q24) may be the cause of the spermatogenesis arrest in infertile twin brothers. Gene in the point of translocation may be related to spermatogenesis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Spermatogenesis
/
Testis
/
Translocation, Genetic
/
Biopsy
/
Chromosomes, Human, Pair 1
/
Chromosomes, Human, Pair 12
/
Diseases in Twins
/
Genetics
/
Infertility, Male
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2002
Type:
Article
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