Detection of serum anti-F antibody in hepatitis C virus infected patients / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 1116-1118, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-322879
ABSTRACT
<p><b>OBJECTIVE</b>To assess the prevalence of serum anti-F in patients with hepatitis C virus (HCV) infection and the distribution of anti-F.</p><p><b>METHODS</b>The recombinant protein (HCV-F/GST) was coated onto micro titer plates as antigen. Sera of 120 patients with hepatitis C virus infection, 15 patients with hepatitis B, 3 patients with hepatitis E and 10 normal sera were tested by indirect ELISA for detecting anti-F.</p><p><b>RESULTS</b>82 samples out of the 120 (68%) HCV infected patients exhibited a positive anti-F reaction, showing significant difference from the controls with no HCV infection (P < 0.01). Data from logistic analysis showed that the positive rate of anti-F was higher in patients over 50 year olds (OR = 6.675, 95% CI 2.407-19.071). Patients of midrange, severe phase and hepatic cirrhosis had higher rate than the others (OR = 2.749, 95% CI 1.470-5.141).</p><p><b>CONCLUSION</b>Prevalence and distribution of anti-F in Yixing hepatitis C patients was reported and which might be related to the progression of HCV infection.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Enzyme-Linked Immunosorbent Assay
/
Hepatitis Antibodies
/
China
/
Viral Core Proteins
/
Prevalence
/
Hepatitis C
/
Hepacivirus
/
Hepatitis C Antigens
/
Allergy and Immunology
Type of study:
Diagnostic study
/
Prevalence study
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2007
Type:
Article
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