Study on the serological diagnosis of Epstein-Barr virus among patients with mononucleosis / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 898-900, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-322900
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship of Epstein-Barr virus (EBV) specific antibodies detection and the diagnoses of infectious mononucleosis (IM) caused by EBV.</p><p><b>METHODS</b>Single serum samples were collected from 220 inpatients with the diagnosis of IM between January 2005 and December 2006 in Beijing Children's hospital. The samples were detected for EBV-CA-IgM, EBV-CA-IgG, EBV-EA-IgG, EBV-NA-IgG and the avidity of EBV-CA-IgG by indirect immunofluorescent assay.</p><p><b>RESULTS</b>The positive rate of EBV-CA-IgG, EBV-CA-IgM, EBV-EA-IgG and EBV-NA-IgG were 100%, 95.9%, 79.5% and 4.1% respectively. Low-avidity EBV-CA-IgG was detected in 204 patients (92.7%) with positive EBV-CA-IgM and EBV-CA-IgG,negative EBV-NA-IgG, low-avidity EBV-CA-IgG were the main pattern of EBV antibody in IM patients (84.6%).</p><p><b>CONCLUSION</b>The existence of EBV specific antibody (CA-IgG, CA-IgM, EA-IgG, NA-IgG and avidity of CA-IgG) could add more information to identify the stage of EBV infection so as to provide more reliable serological evidence for the diagnosis of IM.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Blood
/
Immunoglobulin G
/
Herpesvirus 4, Human
/
Fluorescent Antibody Technique, Indirect
/
Epstein-Barr Virus Infections
/
Diagnosis
/
Allergy and Immunology
/
Infectious Mononucleosis
/
Antibodies, Viral
Type of study:
Diagnostic study
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2007
Type:
Article
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