Progress in the study of acid-sensitive micelles for the targeting drug delivery system / 药学学报
Acta Pharmaceutica Sinica
;
(12): 440-445, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-323022
ABSTRACT
As a novel targeting drug delivery system, acid-sensitive micelles have many advantages, such as increasing solubility of lipophilic drugs, acid-sensitive release, high drug loading, etc. They can load drugs though non-covalent encapsulation and covalent conjugation methods. In tumor tissues, drugs are released quickly from the depolymerized micelles with lipophilic copolymer protonation or lypohydrophilic copolymer hydrolysis and covalent conjugated drugs are released when the acid-sensitive covalent linkage breaks. This review mainly advances acid-sensitive micelles for the tumor targeting drug delivery systems from drug-loaded methods and release mechanisms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Polyethylene Glycols
/
Polymers
/
Drug Carriers
/
Doxorubicin
/
Chemistry
/
Drug Delivery Systems
/
Paclitaxel
/
Cell Line, Tumor
/
Hydrogen-Ion Concentration
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS