Synthesis of diethylenetriamine polydentate ligands and their DNA-cleaving activity / 药学学报
Acta Pharmaceutica Sinica
;
(12): 380-384, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-323032
ABSTRACT
A series of multinuclear diethylenetriamine ligands were synthesized and used as artificial nuclease enzyme model. Target compounds were characterized by 1H NMR, 13C NMR, IR and ESI-MS. Preliminary studies on the cleavage of pUC19 DNA in the presence of metal complexes have also been performed and the results revealed that these complexes could act as powerful catalysts for the cleavage of pUC19 DNA after 48 h under physiological conditions. The hydrolytic cleavage mechanism of DNA plasmid by title compound was confirmed by T4 DNA ligase experiment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyamines
/
Spectrophotometry, Infrared
/
DNA
/
Magnetic Resonance Spectroscopy
/
Chemistry
/
Spectrometry, Mass, Electrospray Ionization
/
DNA Cleavage
/
Ligands
/
Metabolism
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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