Chemical approaches for trapping protein thiols and their oxidative modification / 药学学报
Acta Pharmaceutica Sinica
;
(12): 280-290, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-323045
ABSTRACT
Redox signal transduction, especially the oxidative modification of proein thiols, correlates with many diseases and becomes an expanding research area. However, there was rare method for quick and specific detection of protein thiols and their oxidative modification in living cells. In this article, we review the current chemical strategies for the detection and quantification of protein thiols and related cysteine oxidation. We also look into the future of the development of fluorescent probes for protein thiols and their potential application in the research of reactive cysteine proteomes and early detection of redox-related diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidation-Reduction
/
Sulfenic Acids
/
Sulfhydryl Compounds
/
Proteins
/
Nitrosation
/
Chemistry
/
Reactive Oxygen Species
/
Cysteine
/
Reactive Nitrogen Species
/
Fluorescent Dyes
Type of study:
Screening study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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