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The preparation of paeonol transdermal delivery systems based on the microemulsion-based gels and its pharmacokinetics characters / 药学学报
Acta Pharmaceutica Sinica ; (12): 244-249, 2012.
Article in Chinese | WPRIM | ID: wpr-323050
ABSTRACT
Investigation of the pharmacokinetics of paeonol microemulsion, microemulsion-based gels and marketed paeonol ointments by the skin-blood synchronous microdialysis coupled with LC/MS is reported in this study. The microdialysis systems were established by linear probes and concentric circles probes. In vivo recovery of paeonol in skin is (69.7 +/- 4.8) % and in blood is (51.6 +/- 7.2)%. The paeonol microemulsion, microemulsion-based gels and marketed paeonol ointments were administered to rats. PBS (pH 7.4) served as perfused solution. The perfusion rate was 5 microL x mL(-1) and the microdialysis samples were collected every 20 min intervals. The paeonol concentration in perfused solution was determined by LC/MS. The results showed that paeonol microemulsion and microemulsion-based gels significantly raised the drug concentrations in skin more than that of paeonol ointments. The paeonol microemulsion-based gels has similar bioavailability as the paeonol ointments in blood, but its blood drug concentrations were steadier. The paeonol microemulsion-based gels may be developed into a new preparation for dermis eczema. The skin-blood synchronous microdialysis technique proved to be a new method for the pharmacokinetics study of transdermal delivery systems.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Acetophenones / Skin / Skin Absorption / Mass Spectrometry / Blood / Administration, Cutaneous / Pharmacokinetics / Biological Availability / Chromatography, Liquid / Drug Delivery Systems Limits: Animals Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Acetophenones / Skin / Skin Absorption / Mass Spectrometry / Blood / Administration, Cutaneous / Pharmacokinetics / Biological Availability / Chromatography, Liquid / Drug Delivery Systems Limits: Animals Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2012 Type: Article