Synthesis and anti-tumor activity of paeonol and its derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 72-76, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-323078
ABSTRACT
A series of paeonol derivatives have been synthesized by simple acylation and etherification of the paeonol. Anti-tumor activities of the synthesized compounds were evaluated against HeLa and MCF-7 cells lines in vitro by the standard MTT assay. It was found that the derivatives were more active against HeLa than MCF-7. The results also indicated that 4-methoxy group is the synergistic group of paeonol's anti-tumor activity and ketone carbonyl side chain is essential functional group of paeonol's anti-tumor activity. Compound 2d had stronger antiproliferative activities than paeonol against HeLa and MCF-7 cell lines with IC50 values of 2.67 and 4.74 micromol x L(-1) respectively. The results showed that paeonol derivatives were worth to be intensively studied further.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Acetophenones
/
Pharmacology
/
Structure-Activity Relationship
/
Drug Screening Assays, Antitumor
/
HeLa Cells
/
Chemistry
/
Inhibitory Concentration 50
/
Cell Proliferation
/
MCF-7 Cells
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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