Research progress of the selective sphingosine-1-phosphate receptor 1 agonists / 药学学报
Acta Pharmaceutica Sinica
;
(12): 7-17, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-323087
ABSTRACT
Sphingosine-1-phosphate (S1P) is a lysophospholipid signaling molecule that regulates important biological functions in both intracellular and extracellular compartments. It interacts with five G protein-coupled receptors subtypes (S1PR(1-5)) to generate multiple downstream signaling. Activation of S1PR1 has been validated to be involved in the process of immune modulation. Fingolimod (FTY720), the novel S1PR1 agonist, has been approved for the treatment of multiple sclerosis in clinical trials. The study towards discovery of selective S1PR1 agonists has become hot spot for immunological diseases. This article summarized the research progress of S1PR1 agonists, emphasizing their structure types, structure-activity relationship and direction of development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Propylene Glycols
/
Sphingosine
/
Structure-Activity Relationship
/
Lysophospholipids
/
Classification
/
Therapeutic Uses
/
Receptors, Lysosphingolipid
/
Drug Therapy
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article
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