Study on semi-synthetic transforming technology for the natural product of isocorydione / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1471-1475, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-323099
ABSTRACT
Transforming technology for semi-synthesized isocorydione from the natural product ofisocorydine was studied. The factors affecting on the reaction yield were investigated. UV spectrophotometry was used to indicate the semi-synthesized yield of isocorydione. The optimum reaction conditions were determined as following reacting for 12 h in the solution of sodium dihydrogen phosphate at pH 10, the temperature was 25 degrees C and the ratio of isocorydine to Fremy's radical was 1 2. Under the optimum conditions, the yield could reach up to 50.0%. The molecular structure of isocorydione was elucidated by X-ray single-crystal diffraction analysis for the first time.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidation-Reduction
/
Aporphines
/
Plants, Medicinal
/
Spectrophotometry, Ultraviolet
/
Temperature
/
X-Ray Diffraction
/
Molecular Structure
/
Chemistry
/
Crystallography, X-Ray
/
Papaveraceae
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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