Effects of Astaxanthin on the damage of osteoblast induced by H2O2 / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 187-189, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-323181
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Astaxanthin on enhancing the function of anti-oxidative damage in osteoblast.</p><p><b>METHODS</b>MC3T3-E1 osteoblasts were randomly divided into five groups, including control group, model group, Astaxanthin group [low-dose (1 x 10(-7) mol/L), middle-dose (1 x 10(-6) mol/L), high-dose (1 x 10(-5) mol/L)], in which the activity of cells, activity of superoxide dismutase (SOD), the content of reactive oxygen species (ROS), lipid oxygen (LPO) and membrane fluidity were tested and compared.</p><p><b>RESULTS</b>Compared with Astaxanthin groups, the activity of cells, SOD activity and membrane fluidity in the model group were significantly decreased (P < 0.01). However, the contents of ROS and LPO were significantly raised (P < 0.01).</p><p><b>CONCLUSION</b>H2O2 can cause oxidative damage of MC3T3-E1 osteoblasts, but Astaxanthin can prevent or decrease its influence.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Pharmacology
/
Superoxide Dismutase
/
Lipid Peroxidation
/
Cell Line
/
Chemistry
/
Reactive Oxygen Species
/
Oxidative Stress
/
Xanthophylls
/
Hydrogen Peroxide
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2008
Type:
Article
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