Expression of TGF-beta1 mRNA in prostate carcinoma tissues and its significance / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression of TGF-beta1 mRNA in prostate carcinoma tissues and its significance.</p><p><b>METHODS</b>RT-PCR method was used to examine the expression of TGF-beta1 mRNA in normal and carcinomatous prostate tissues.</p><p><b>RESULTS</b>The relative content of TGF-beta1 mRNA of normal prostate tissues was (0.74 +/- 0.11), while those of carcinomatous prostate tissues at T1-T2 and T3-T4 stages were (0.69 +/- 0.10) and (0.44 +/- 0.08) respectively, with significant difference between T1-T2 and T3-T4 (P < 0.05). And the relative contents of TGF-beta1 mRNA of carcinomatous prostate tissues with Gleason score < or = 5, 6-8 and > or = 9 were (0.70 +/- 0.12), (0.54 +/- 0.11) and (0.42 +/- 0.09) respectively.</p><p><b>CONCLUSION</b>The expression of TGF-beta1 mRNA was negatively correlated with the clinical stage and Gleason score of prostate carcinoma.</p>