Significance of MMP2 and MMP9 expression in prostate cancer / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the significance of the expression of matrix metalloproteinases (MMPs) in prostate cancer (PCa) and its clinical association.</p><p><b>METHODS</b>Fifty one cases of PCa and 10 cases of BPH were studied by immunohistochemical method using monoclonal antibodies to MMP2 and MMP9.</p><p><b>RESULTS</b>There was significant correlation between MMP2 or MMP9 and pathological grade, Gleason score and PCa metastasis.</p><p><b>CONCLUSION</b>The expression of MMP2 and MMP9 may play an important role in the development and metastasis of PCa.</p>