Acute Effect of Methylprednisolone in Experimental Spinal Cord Injury
Journal of Korean Neurosurgical Society
;
: 521-528, 1983.
Article
in Korean
| WPRIM
| ID: wpr-32342
ABSTRACT
It is the purpose of this study to determine the benificial effect of treatment with methylprednisolone on the enhancement of Na+, K+-ATPase activity and the increased ATP level during the 4 hours after a 400gm-cm injury to the spinal cord of cat. These results demonstrate that high dose (30mg/kg) of methylprednisolone can benificially enhance the activity of neuronal Na+, K+-ATPase during the first 4 hour after spinal cord injury. But the enhancement of this enzyme activity is not significantly increased with mega dose (60mg/kg) of methylprednisolone. Tissue level of ATP in the high dose-treated cat at 1 hour after trauma was significantly elevated, but those in high dose-treated cat at 4 hour and the 1 and 4 hours with mega dose-treated groups were not significantly increased. The protective effects of methylprednisolone in experimental spinal cord trauma are the enhancement of Na+, K+-ATPase, inhibition of the free-radical reaction and the lipid peroxidation, the increment of neuronal activity and ATP utilization. High dose(30mg/kg) of methylprednisolone is required in order to produce the acute effect in the early phase experimental spinal cord injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord
/
Spinal Cord Injuries
/
Methylprednisolone
/
Lipid Peroxidation
/
Adenosine Triphosphate
/
Neurons
Limits:
Animals
Language:
Korean
Journal:
Journal of Korean Neurosurgical Society
Year:
1983
Type:
Article
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