Clinical study of blood type A donor liver transplantation in type O recipients / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the clinical effect and feasibility of blood type A donor liver transplantation in blood type O recipients.</p><p><b>METHODS</b>The clinical data were analyzed in 6 blood type O patients receiving transplantation of the liver grafts from blood type A donors. The clinical effect and outcomes of the transplantations were evaluated to assess the feasibility of ABO incompatible liver transplantation between type A donors and type O recipients.</p><p><b>RESULTS</b>The operations and the postoperative recovery were smooth in all the 6 recipients. Only one patient died 5 months postoperatively due to liver tumor metastasis, and the other 5 patients survived with the longest survival reaching 14 months. Acute graft rejection occurred in one patient 1 week after the operation on account of abnormally elevated serum bilirubin level, which was successfully managed with immediate methylprednisolone therapy. No such complications as acute graft rejection, bile duct stenosis or bile leakage was found in the other patients.</p><p><b>CONCLUSION</b>Blood type A donor liver transplantation in type O recipient is feasible in emergency or other special conditions.</p>