Effect of invasive and non-invasive positive pressure ventilation on plasma brain natriuretic peptide in patients with chronic obstructive pulmonary disease and severe respiratory failure / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2377-2379, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-323656
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the change in plasma brain natriuretic peptide (BNP) in patients with chronic obstructive pulmonary disease (COPD) and severe respiratory failure receiving invasive or non-invasive positive pressure ventilation.</p><p><b>METHODS</b>Fifty-six patients with COPD and severe respiratory failure were randomized into non-invasive ventilation group (n=28) to receive facial mask ventilation and invasive ventilation group (n=28) to have mechanical ventilation by tracheal intubation or tracheal incision. The changes of blood gas and BNP before and 24 h after the ventilation were observed.</p><p><b>RESULTS</b>The indexes of blood gas analysis such as pH, PO2 and PaCO2 in the invasive ventilation group were better than those in the non-invasive ventilation group (P<0.05). The plasma levels of BNP of the invasive ventilation group were much lower 24 h after the treatment than that of the non-invasive ventilation group (P<0.05).</p><p><b>CONCLUSION</b>Invasive ventilation produces better effect than non-invasive ventilation in the treatment of COPD with severe respiratory failure. Plasma concentrations of BNP has significant clinical value to evaluate the effect of mechanical ventilation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory Insufficiency
/
Therapeutics
/
Blood
/
Positive-Pressure Respiration
/
Natriuretic Peptide, Brain
/
Pulmonary Disease, Chronic Obstructive
/
Noninvasive Ventilation
/
Methods
Type of study:
Controlled clinical trial
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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