Toxicity of matrine in Kunming mice / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2154-2155, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-323708
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the acute toxicity and assess the median lethal dose (LD50) of matrine in Kunming mice.</p><p><b>METHODS</b>Matrine at different doses were administered in Kunming mice via intraperitoneal injection, and the toxic reactions and LD50 of matrine was observed and determined.</p><p><b>RESULTS</b>The acute toxicity test of matrine indicated that the tolerable dose of matrine was above 80 mg/kg in Kunming mice, and the LD50 was 157.13 mg/kg (95%CI, 88.08-280.31 mg/kg). Morphological observation revealed degenerative changes of the nerve cells in the brain tissue of the mice.</p><p><b>CONCLUSION</b>The nervous system is the main target organ by the toxicity of matrine.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Quinolizines
/
Brain
/
Toxicity Tests, Acute
/
Alkaloids
/
Toxicity
/
Lethal Dose 50
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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