Renal protective effects of benidipine and valsartan in primary hypertension patients with proteinuria / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 20-22, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-323885
ABSTRACT
<p><b>OBJECTIVE</b>To compare the renal protective effects between calcium channel blocker benidipine and angiotensin II receptor blocker valsartan in primary hypertension patients with proteinuria.</p><p><b>METHODS</b>A total of 236 patients were divided to low (< 1 g/24 h) and high (1 - 3 g/24 h) proteinuria groups and treated with benidipine (8 mg/d) or valsartan (80 mg/d) for 48 weeks. Blood pressure, glomerular filtration rate (GFR) and 24 h protein were measured at baseline, 12, 24 and 48 weeks.</p><p><b>RESULTS</b>Blood pressure was significantly and equally reduced in all treated groups (all P < 0.05 vs. baseline). GFR was also significantly and equally improved in all treated groups after 24 weeks treatments (all P < 0.05 at 24 weeks and 48 weeks). Proteinuria reduction at 24 and 48 weeks was more significant in patients treated with valsartan compared to patients treated with benidipine in low proteinuria group [24 weeks (0.27 +/- 0.07) g/24 h vs. (0.39 +/- 0.06) g/24 h, P < 0.01; 48 weeks (0.18 +/- 0.01) g/24 h vs. (0.30 +/- 0.05) g/24 h, P < 0.01].</p><p><b>CONCLUSION</b>The renal protection efficacy of valsartan and benidipine was similar in primary hypertensive patients with proteinuria.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Proteinuria
/
Tetrazoles
/
Valine
/
Dihydropyridines
/
Calcium Channel Blockers
/
Therapeutic Uses
/
Drug Therapy
/
Angiotensin Receptor Antagonists
/
Valsartan
/
Glomerular Filtration Rate
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2010
Type:
Article
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