Plasma proteomic analysis in male normotensive, prehypertensive and hypertensive subjects / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To compare the plasma proteome among male normotensive, prehypertensive, and hypertensive subjects.</p><p><b>METHODS</b>Plasma proteome was analyzed by two-dimensional electrophoresis combined with MALDI-TOF mass spectrometry in this case-control study among well matched male normotensive, prehypertensive and hypertensive subjects (n = 26 each).</p><p><b>RESULTS</b>The results showed that there were 22 differentially expressed protein spots among the protein samples derived from the 3 groups which corresponded to 18 proteins associated with inflammation and immunity, lipid metabolism, transport, coagulation and fibrinolysis, cell proliferation and apoptosis, and antioxidation.</p><p><b>CONCLUSION</b>Proteins were differentially expressed in male subjects with various blood pressure levels.</p>