Association between wnt signal pathway and post-infarction cardiac remodeling/rupture in aged mice / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 826-831, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-323969
ABSTRACT
<p><b>OBJECTIVE</b>To observe the association between wnt signal pathway and post infarction left ventricular remodeling/rupture in mice with various ages.</p><p><b>METHODS</b>Three months-old (young group, n = 116) and 18 months-old (aged group, n = 116) male C57/BL mice were studied. Seventy mice underwent ligation of left coronary artery, 10 sham-operation and echocardiography and hemodynamics were performed 7 d post-infarction, 36 infarcted mice were used for detecting expression of dvl-1, beta-catenin and connexin 43 in left ventricular (LV) myocardium and infarction region at 3 d, 7 d, 14 d post infarction (n = 12 each).</p><p><b>RESULTS</b>Incidence of cardiac rupture was significantly higher in aged mice than in young mice (36.7% vs. 16.7%, P < 0.05) and degree of LV dilation and contractile dysfunction was significantly severer in aged mice than those in young mice post infarction. Expression of dvl-1, beta-catenin in left ventricle was upregulated in MI group compared with sham group (P < 0.05), expression of dvl-1 and beta-catenin in infarction region in MI 3d group in aged mice was significantly downregulated than in young mice (P < 0.05). Expression of connexin 43 is 2.15 fold higher in young sham mice than in aged sham mice (P < 0.05) and decreased significantly post infarction (P < 0.05). Expression of connexin 43 in infarction region in mice 3 d and 14 d post infarction was significantly lower in aged mice than in respective young mice (all P < 0.05).</p><p><b>CONCLUSION</b>Reductant activation of wnt signal pathway post infarction in aged mice might be responsible for increased incidence of cardiac rupture and aggravated remodeling.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Aging
/
Signal Transduction
/
Ventricular Remodeling
/
Wnt Proteins
/
Heart Rupture
/
Heart Ventricles
/
Metabolism
/
Mice, Inbred C57BL
/
Myocardial Infarction
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2009
Type:
Article
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