Expression of PN3 and NaN in trigeminal ganglion during occlusal trauma in rat / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate changes of two sodium channels, PN(3) and NaN, during orofacial pain by occlusal trauma in rat.</p><p><b>METHODS</b>Expressions of PN(3) mRNA and NaN mRNA in trigeminal ganglion were tested during various periods of persistent occlusal trauma with reverse transcription-polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>In groups, including control, occlusal trauma groups, PN(3) mRNA and NaN mRNA were all expressed in trigeminal ganglion neurons. In the control group, there were similar density values bilaterally. In the occlusal trauma group, the density values in gel electrophoresis of PN(3) mRNA and NaN mRNA on the intervention side were slightly greater than those on the control side.</p><p><b>CONCLUSIONS</b>The stimulation of occlusal trauma upregulates expressions of PN(3) mRNA and NaN mRNA, which suggests the signal occurring and conduction of chronic pain by occlusal trauma have the same molecular mechanism of sodium channel as inflammatory pain.</p>