Pharmacokinetic study on baicalin of Qingkailing injection in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2534-2538, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-324332
ABSTRACT
<p><b>OBJECTIVE</b>Studying the metabolic pharmacokinetic of baicalin of Qingkailing injection in rat, to search for effector substance of Qingkailing injection in vivo.</p><p><b>METHOD</b>Qingkailing sterile injection powder was given by caudal vein, then blood, liver and lung were collected in various time, the concentration of baicalin from samples were determined by HPLC-MS. Pharmacokinetic evaluation was carried out using the 3P87.</p><p><b>RESULT</b>After Qingkailing injection, Baicalin was consistent with two-compartment model in rat. 45 min, the concentration of baicalin in hepatic tissue reached maximum, followeded by decrease sharply, 120 min began to rise slowly, present double hump phenomenon. In lung, baicalin concentration was far more than in liver, was eliminated more slowly, but they have the same t(max).</p><p><b>CONCLUSION</b>After Qingkailing injection, baicalin distributed quickly to liver and lung, baicalin is one of effector substance of qingkailing injection in vivo. Baicalin might have hepatoenteral circulation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Powders
/
Mass Spectrometry
/
Flavonoids
/
Blood
/
Drugs, Chinese Herbal
/
Materia Medica
/
Pharmacokinetics
/
Metabolic Clearance Rate
/
Random Allocation
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
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