Decreased renal vitamin K-dependent gamma-glutamyl carboxylase activity in calcium oxalate calculi patients / 中华医学杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To study the activity of vitamin K-dependent gamma-glutamyl carboxylase in patients with calcium oxalate (CaOx) urolithiasis compared with healthy individuals and to assess its relationship to the renal calcium oxalate urolithiasis.</p><p><b>METHODS</b>Renal parenchymas were harvested from urolithic patients and renal tumor patients undergoing nephrectomy. The renal carboxylase activity was evaluated as the radioactivity of [(14)C] labeled sodium bicarbonate in carboxylic reactions in vitro using beta-liquid scintillation counting.</p><p><b>RESULTS</b>Significantly reduced activity of renal vitamin K-dependent gamma-glutamyl carboxylase was observed in the urolithic group as compared with normal controls (P < 0.01).</p><p><b>CONCLUSION</b>It suggests that the reduced carboxylase activity observed in the urolithic patients may play an important role in the course of renal calcium oxalate urolithiasis.</p>