Fish interferon response and its molecular regulation: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 675-683, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-324551
ABSTRACT
Interferon response is the first line of host defense against virus infection. Recent years have witnessed tremendous progress in understanding of fish innate response to virus infection, especially in fish interferon antiviral response. A line of fish genes involved in interferon antiviral response have been identified and functional studies further reveal that fish possess an IFN antiviral system similar to mammals. However, fish virus-induced interferon genes contain introns similar to mammalian type III interferon genes although they encode proteins similar to type I interferons, which makes it hard to understand the evolution of vertebrate interferon genes directly resulting in a debate on nomenclature of fish interferon genes. Actually, fish display some unique mechanisms underlying interferon antiviral response. This review documents the recent progress on fish interferon response and its molecular mechanism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Virus Diseases
/
Gene Expression Regulation
/
Interferons
/
Fish Proteins
/
Allergy and Immunology
/
STAT1 Transcription Factor
/
Fish Diseases
/
Fishes
/
Genetics
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2011
Type:
Article
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