From pro-prostate specific antigen, -2pro-prostate specific antigen to Beckman Coulter phi: the evolution of new biomarkers for early detection of prostatic carcinoma / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1643-1649, 2012.
Article
in English
| WPRIM
| ID: wpr-324921
ABSTRACT
Prostate specific antigen (PSA) has a wide clinical use for the early detection of prostatic carcinoma (PCa); however, it has never been a perfect marker due to its low specificity and low positive predictive value which ranges between 4 ng/ml and 10 ng/ml. The discovery of different PSA molecular forms in serum in the early 1990s brought insight into searching for more specific markers. Since then free PSA (fPSA) has been used routinely to increase the specificity for PCa and to reduce unnecessary biopsies. More recently, promising data is emerging regarding one proenzyme molecular form of free PSA, proPSA, and a few truncated proPSA isoforms. The purpose of this article is to review the recent studies on clinical utility of proPSA, especially [−2]pPSA, an isoform of proPSA, and parameters involving [−2]pPSA as well as other PSA derivatives in early detection of PCa.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatic Neoplasms
/
Biomarkers, Tumor
/
Prostate-Specific Antigen
/
Diagnosis
/
Metabolism
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2012
Type:
Article
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