Factors associated with post-pancreaticoduodenectomy hemorrhage: 303 consecutive cases analysis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1571-1575, 2012.
Article
in English
| WPRIM
| ID: wpr-324934
ABSTRACT
<p><b>BACKGROUND</b>Because of the complexity and severity of the surgery and its associated complications, pancreaticoduodenectomy (PD) is associated with significant morbidity and mortality, especially the hemorrhage post-PD. Exploring the factors associated with post-PD hemorrhage is very important for the patients' safety.</p><p><b>METHODS</b>Clinical data from 303 cases of PD between January 1998 and December 2008 were analyzed retrospectively.</p><p><b>RESULTS</b>The overall mortality rate was 4.95% (15/303). However, post-operative bleeding occurred in 25 patients (8.25%) with nine episodes resulting in death (36.00%). Univariate analysis was performed and identified tumor size, Child's classification, total pancreatic uncinatic process resection, and pancreatic leakage as significant risk factors for post-PD hemorrhage. In the severe hemorrhage group, incomplete resection of uncinate process of pancreas and pancreatic leakage were the main causes. The multivariate Logistic regression analysis revealed that each of these variables is an independent risk factor.</p><p><b>CONCLUSIONS</b>Primary prevention of bleeding complications depends on total pancreatic uncinatic process resection and meticulous hemostatic techniques during surgery. In addition, several peri-operative factors were found to contribute to post-PD bleeding.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Risk Factors
/
Mortality
/
Pancreaticoduodenectomy
/
Postoperative Hemorrhage
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2012
Type:
Article
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